Quantitative Analysis of the Effect of an Ectopic Beat on the Heart Rate Variability in the Resting Condition

The purpose of this study is to quantitatively analyze the effect of an ectopic beat on heart rate variability (HRV) in the time domain, frequency domain, and in a non-linear analysis. A quantitative analysis was carried out by generating artificial ectopic beats that probabilistically contained a missed beat or a false-detected beat, and the statistical significance was evaluated though a comparison with an ectopic-free HRV by increasing the ratio of the ectopic beat in 0.1% increments from 0 to 50%. The effect of the interpolation on the ectopic HRV was also investigated by applying nearest-neighbor interpolation, linear interpolation, and cubic spline interpolation. The results confirmed a statistically significant difference (P < 0.05) even in the less-than-1% ectopic HRV in every domain. When interpolation was applied, there were differences according to the interpolation method used, but statistical significance was secured for an ectopic beat ratio from 1 to 2% to several tens of a percent. In the effect, linear interpolation, and spline interpolation were confirmed to have a higher effect on the high-frequency related HRV variables, and nearest-neighbor interpolation had a higher effect on low-frequency related variables

The 2023 wearable photoplethysmography roadmap

Photoplethysmography is a key sensing technology which is used in wearable devices such as smartwatches and fitness trackers. Currently, photoplethysmography sensors are used to monitor physiological parameters including heart rate and heart rhythm, and to track activities like sleep and exercise. Yet, wearable photoplethysmography has potential to provide much more information on health and wellbeing, which could inform clinical decision making. This Roadmap outlines directions for research and development to realise the full potential of wearable photoplethysmography. Experts discuss key topics within the areas of sensor design, signal processing, clinical applications, and research directions. Their perspectives provide valuable guidance to researchers developing wearable photoplethysmography technology

Deep Convolutional Neural Network-Based Hemiplegic Gait Detection Using an Inertial Sensor Located Freely in a Pocket

In most previous studies, the acceleration sensor is attached to a fixed position for gait analysis. However, if it is aimed at daily use, wearing it in a fixed position may cause discomfort. In addition, since an acceleration sensor can be built into the smartphones that people always carry, it is more efficient to use such a sensor rather than wear a separate acceleration sensor. We aimed to distinguish between hemiplegic and normal walking by using the inertial signal measured by means of an acceleration sensor and a gyroscope. We used a machine learning model based on a convolutional neural network to classify hemiplegic gaits and used the acceleration and angular velocity signals obtained from a system freely located in the pocket as inputs without any pre-processing. The classification model structure and hyperparameters were optimized using Bayesian optimization method. We evaluated the performance of the developed model through a clinical trial, which included a walking test of 42 subjects (57.8 ± 13.8 years old, 165.1 ± 9.3 cm tall, weighing 66.3 ± 12.3 kg) including 21 hemiplegic patients. The optimized convolutional neural network model has a convolutional layer, with number of fully connected nodes of 1033, batch size of 77, learning rate of 0.001, and dropout rate of 0.48. The developed model showed an accuracy of 0.78, a precision of 0.80, a recall of 0.80, an area under the receiver operating characteristic curve of 0.80, and an area under the precision–recall curve of 0.84. We confirmed the possibility of distinguishing a hemiplegic gait by applying the convolutional neural network to the signal measured by a six-axis inertial sensor freely located in the pocket without additional pre-processing or feature extraction

Recurrence Plot and Machine Learning for Signal Quality Assessment of Photoplethysmogram in Mobile Environment

The purpose of this study was to develop a machine learning model that could accurately evaluate the quality of a photoplethysmogram based on the shape of the photoplethysmogram and the phase relevance in a pulsatile waveform without requiring complicated pre-processing. Photoplethysmograms were recorded for 76 participants (5 min for each participant). All recorded photoplethysmograms were segmented for each beat to obtain a total of 49,561 pulsatile segments. These pulsatile segments were manually labeled as ‘good’ and ‘poor’ classes and converted to a two-dimensional phase space trajectory image using a recurrence plot. The classification model was implemented using a convolutional neural network with a two-layer structure. As a result, the proposed model correctly classified 48,827 segments out of 49,561 segments and misclassified 734 segments, showing a balanced accuracy of 0.975. Sensitivity, specificity, and positive predictive values of the developed model for the test dataset with a ‘poor’ class classification were 0.964, 0.987, and 0.848, respectively. The area under the curve was 0.994. The convolutional neural network model with recurrence plot as input proposed in this study can be used for signal quality assessment as a generalized model with high accuracy through data expansion. It has an advantage in that it does not require complicated pre-processing or a feature detection process

Simple and Robust Realtime QRS Detection Algorithm Based on Spatiotemporal Characteristic of the QRS Complex.

The purpose of this research is to develop an intuitive and robust realtime QRS detection algorithm based on the physiological characteristics of the electrocardiogram waveform. The proposed algorithm finds the QRS complex based on the dual criteria of the amplitude and duration of QRS complex. It consists of simple operations, such as a finite impulse response filter, differentiation or thresholding without complex and computational operations like a wavelet transformation. The QRS detection performance is evaluated by using both an MIT-BIH arrhythmia database and an AHA ECG database (a total of 435,700 beats). The sensitivity (SE) and positive predictivity value (PPV) were 99.85% and 99.86%, respectively. According to the database, the SE and PPV were 99.90% and 99.91% in the MIT-BIH database and 99.84% and 99.84% in the AHA database, respectively. The result of the noisy environment test using record 119 from the MIT-BIH database indicated that the proposed method was scarcely affected by noise above 5 dB SNR (SE = 100%, PPV > 98%) without the need for an additional de-noising or back searching process

Longitudinal Healthcare Data Management Platform of Healthcare IoT Devices for Personalized Services

Recently, many studies have been conducted on how to manage and analyze various types of health data such as clinical data, genomic data, and wirelessly collected multiple sensory data. In this paper, we propose a web-based healthcare data integration and management platform that collects heterogeneous types of health-related medical record as well as real-time lifelogging data. This platform provides flexible architecture to different types of data exchanges. The platform manages real-time data such as heart rate, blood pressure, and activity information extracted from various healthcare devices and provides functions to transmit them to the server. Then it analyses the risk based on a domain knowledge and individual differences by applying machine learning tools, then visualizes the result to the patient and doctor dynamically based on information simplification method. It also controls the data access authority concerning the level of expertise and role. For evaluation of integrated data analysis, we apply open database and evaluate the proposed risk analyser result. The proposed platform could be utilized for future healthcare service to share accumulated healthcare data in various situations

The original ECG signal and the scaled output of the level stabilizer (the dashed line is the energy level threshold.)

<p>The original ECG signal and the scaled output of the level stabilizer (the dashed line is the energy level threshold.)</p

Detection of Hemiplegic Walking Using a Wearable Inertia Sensing Device

Hemiplegia is a symptom that is caused by reduced sensory and motor ability on one side of the body due to stroke-related neural defects. Muscular weakness and abnormal sensation that is induced by hemiplegia usually lead to motor impairments, such as difficulty in controlling the trunk, unstable balance, and poor walking ability. Therefore, most hemiplegia patients show defective and asymmetric gait pattern. The purpose of this study is to distinguish hemiplegic gait by extracting simple characteristics of acceleration signals that are caused by asymmetry during walking using a wearable system. The devised wearable system was equipped with a three-axis accelerometer and a three-axis gyroscope. We selected 165 candidate features without step detection. A random forest algorithm was used for the classification, and the forward search algorithm was also used for optimal feature selection. The developed system and algorithms were verified clinically in 15 normal subjects and 20 hemiplegia patients that were undergoing stroke treatment, and 26 subject&rsquo;s data was used for training, including validation, and nine subject&rsquo;s data used for test. As a result of test set, the accuracy, sensitivity, specificity and positive predictive value were 100.0%, with the two classification attributes of standard deviation of points perpendicular to the axis of line of identity of Poincar&eacute; plot of angular velocity around vertical axis and kurtosis of frequency of angular velocity around longitudinal axis